Job Description

Director, Translational Medicine Lead, Hematology

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Job Title: Director, Translational Medicine Lead, Hematology

Location: San Francisco, CA

AstraZeneca is a global, science-led, patient-focused biopharmaceutical company dedicated to discovering, developing, and commercializing medicines for serious diseases. We foster a collaborative and innovative environment, attracting top talent and nurturing growth.

Our flexible work policies allow employees to balance personal and professional commitments, with a collaborative office space designed for team strategizing and connection. We are committed to sustainability, addressing global challenges like climate change, healthcare access, and disease prevention.

Introduction to Role: In Hematology R&D, we aim to advance science and deliver transformative medicines for patients. Our pipeline utilizes six scientific platforms to address unmet needs in hematological cancers, from discovery to late-stage development. The team handles drug development activities from first-in-human studies to regulatory approval, focusing on robust preclinical, clinical, and translational data to support drug approval.

We seek a Director, Translational Medicine Lead in Hematology R&D to lead biomarker development in drug discovery and development, impacting a portfolio from inception to lifecycle management.

Accountabilities:

1. Lead strategic implementation for target identification, indication selection, and patient stratification in Hematology.
2. Deliver and generate biomarkers for clinical studies to guide therapy and patient selection.
3. Measure target engagement and understand pathway interactions to inform drug combinations.
4. Define resistance mechanisms by studying tumors at relapse.
5. Collaborate across Oncology Research to integrate translational strategies in early development.
6. Design and execute phase 1/2a studies to generate safety, PK, PD, and efficacy data.
7. Manage research collaborations and ensure clinical assay quality.
8. Contribute to study reports, data reviews, publications, and scientific recommendations.

Essential Skills/Experience:

• PhD and/or MD with oncology drug development experience.
• Oncology training, preferably board-certified or eligible in Oncology and/or Hematology.
• 5+ years in drug development within pharma or biotech.
• Deep knowledge of hematology biology, with expertise in myeloma, leukemia, and lymphoma.
• Experience with T cell engagers, antibody-drug conjugates, or cell therapies is preferred.
• Strong communication, problem-solving, and collaboration skills.
• Proven leadership in managing complex projects and motivating teams.

Desirable Skills/Experience:

• Additional years of experience and higher education levels are preferred.

More Information:

• Follow AstraZeneca on LinkedIn , Facebook , and Instagram .

Total Rewards: The annual base salary ranges from $172,788.80 to $259,183.20 . Additional benefits include bonus opportunities, equity, retirement plans, paid leave, and health coverage. Details will be provided upon offer.

AstraZeneca is an equal opportunity employer committed to diversity and inclusion, offering accommodations for persons with disabilities upon request.

Seniority level

• Mid-Senior level

Employment type

• Full-time

Job function

• Business Development and Sales

Industries

• Pharmaceutical Manufacturing

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Job Tags

Full time, Immediate start, Flexible hours,

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